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Thus, an effective treatment for diabetes complications including DPN should include some form of an anti-inflammatory component

In normal kidney function the counter current multiplier system, together with the renin-angiotensin-aldosterone system (RAAS), involves extracellular fluid volume control, electrolyte balance, waste product excretion, drug and hormone elimination/metabolism, blood pressure (BP) and haematocrit regulation, and calcium/phosphate balance (vitamin D 3 metabolism)

However, limited accessibility and insurance coverage for advanced diagnostic methods, such as corneal confocal microscopy (CCM) and NCS, pose challenges to their widespread use in population screening